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Issue 72, 2014
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Paclitaxel prodrug nanoparticles combining chemical conjugation and physical entrapment for enhanced antitumor efficacy

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Abstract

This study presents the combination of the prodrug approach with the self-assembly technique by using a poly(ethylene glycol)–paclitaxel (PTX) conjugate as the nanomicellar carrier for delivery of free PTX drugs. The conjugate PEG-PCPGE/PTX readily forms stable micelles in aqueous solution and is used to form an intracellular pool of PTX after the micelles are endocytosed, where encapsulated drug is first released, then destabilized polymer–PTX molecules liberate free PTX following cleavage in the intracellular environment. The use of the conjugate PTX as the core of the micelles provides an ideal affinity site for free PTX, in the mean time, high drug loading and time-programmable delivery are realized.

Graphical abstract: Paclitaxel prodrug nanoparticles combining chemical conjugation and physical entrapment for enhanced antitumor efficacy

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Publication details

The article was received on 26 Jun 2014, accepted on 13 Aug 2014 and first published on 13 Aug 2014


Article type: Paper
DOI: 10.1039/C4RA06270A
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2014,4, 38405-38411
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    Paclitaxel prodrug nanoparticles combining chemical conjugation and physical entrapment for enhanced antitumor efficacy

    X. Hu, J. Li, W. Lin, Y. Huang, X. Jing and Z. Xie, RSC Adv., 2014, 4, 38405
    DOI: 10.1039/C4RA06270A

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