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Issue 50, 2014
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Oxidant- and metal-free synthesis of 4(3H)-quinazolinones from 2-amino-N-methoxybenzamides and aldehydes via acid-promoted cyclocondensation and elimination

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Abstract

A series of biologically important 4(3H)-quinazolinones were readily synthesized in good to excellent yields from 2-amino-N-methoxybenzamides and aldehydes via a cascade reaction consisting of AcOH-promoted cyclocondensation and elimination. The current method sets itself apart from the conventional approach utilizing anthranilamide derivatives and aldehydes as building blocks, by its unique features, other than the high yields and one-pot procedure, including the absence of an oxidant, the elimination of a heavy-metal catalyst, and the formation of a non-toxic ester byproduct.

Graphical abstract: Oxidant- and metal-free synthesis of 4(3H)-quinazolinones from 2-amino-N-methoxybenzamides and aldehydes via acid-promoted cyclocondensation and elimination

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Publication details

The article was received on 14 Apr 2014, accepted on 30 May 2014 and first published on 04 Jun 2014


Article type: Communication
DOI: 10.1039/C4RA04331F
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2014,4, 26434-26438
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    Oxidant- and metal-free synthesis of 4(3H)-quinazolinones from 2-amino-N-methoxybenzamides and aldehydes via acid-promoted cyclocondensation and elimination

    R. Cheng, L. Tang, T. Guo, D. Zhang-Negrerie, Y. Du and K. Zhao, RSC Adv., 2014, 4, 26434
    DOI: 10.1039/C4RA04331F

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