Issue 8, 2014
From the journal:

RSC Advances

Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water†

Alessandro Poma,*a   Antonio Guerreiro,b   Sarah Caygill,b   Ewa Moczkob  and  Sergey Piletskyb  

* Corresponding authors

a Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK
E-mail: alessandro.poma@open.ac.uk

b Chemistry Department, College of Science and Engineering, University of Leicester, UK

Abstract

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, “ready for use” MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours.

Graphical abstract: Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water

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Article information

DOI
https://doi.org/10.1039/C3RA46838K
Article type
Communication
Submitted
19 Nov 2013
Accepted
28 Nov 2013
First published
09 Dec 2013

RSC Adv., 2014,4, 4203-4206

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Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water

A. Poma, A. Guerreiro, S. Caygill, E. Moczko and S. Piletsky, RSC Adv., 2014, 4, 4203 DOI: 10.1039/C3RA46838K

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