Issue 10, 2014

Palladium-catalyzed annulation of internal alkynes in aqueous medium

Abstract

To facilitate precatalyst recovery and reuse, we have developed a fluorous, oxime-based palladacycle 1 and demonstrated that it is a very efficient and versatile precatalyst for carbo- and heteroannulation of internal alkynes with functionalized aryl halides in aqueous medium. A uniform reaction condition for these annulation reactions was also developed.

Graphical abstract: Palladium-catalyzed annulation of internal alkynes in aqueous medium

Supplementary files

Article information

Article type
Paper
Submitted
22 Oct 2013
Accepted
02 Dec 2013
First published
02 Dec 2013

RSC Adv., 2014,4, 4921-4929

Palladium-catalyzed annulation of internal alkynes in aqueous medium

W. J. Ang, C. Tai, L. Lo and Y. Lam, RSC Adv., 2014, 4, 4921 DOI: 10.1039/C3RA46010J

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