Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A–T pair†‡
Abstract
A better than reported abasic duplex stabilization was achieved with the novel triazolylphenanthrene nucleoside TPhenBDo. The large surface area, polarizability and strong stacking propensity of triazolylphenanthrene play a major role in the thermal stabilization of the TPhenBDo–Φ duplex comparable to that of a natural A–T pair via a strong intercalative stacking interaction.