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Issue 44, 2013
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Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A–T pair

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Abstract

A better than reported abasic duplex stabilization was achieved with the novel triazolylphenanthrene nucleoside TPhenBDo. The large surface area, polarizability and strong stacking propensity of triazolylphenanthrene play a major role in the thermal stabilization of the TPhenBDo–Φ duplex comparable to that of a natural A–T pair via a strong intercalative stacking interaction.

Graphical abstract: Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A–T pair

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Publication details

The article was received on 02 Aug 2013, accepted on 23 Aug 2013 and first published on 27 Aug 2013


Article type: Communication
DOI: 10.1039/C3RA44120B
Citation: RSC Adv., 2013,3, 21352-21355
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    Unnatural triazolyl nucleoside stabilizes an abasic site containing DNA duplex equally as the stabilization of a natural A–T pair

    S. S. Bag, R. Kundu and S. Talukdar, RSC Adv., 2013, 3, 21352
    DOI: 10.1039/C3RA44120B

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