Issue 47, 2013

Chemoenzymatic selective formation of C–N bonds in a benzimidazole heterocycle

Abstract

A novel and efficient method for the chemoenzymatic selective formation of C–N bonds in the synthesis of a 2-substituted benzimidazole heterocycle, catalyzed by lipase from porcine pancreas (PPL), has been developed. A series of 2-substituted benzimidazole derivatives were synthesized under mild conditions, with high yields (89–96%) and high selectivity. The blank and control experiments reveal that PPL plays an important catalytic role during the selective C–N bond formation process. The results demonstrate that PPL has a broad catalytic tolerance towards different aldehydes containing electron-donating or -withdrawing groups in this reaction. This study provides an efficient tool for the selective formation of C–N bonds in the synthesis of 2-substituted benzimidazole derivatives.

Graphical abstract: Chemoenzymatic selective formation of C–N bonds in a benzimidazole heterocycle

Supplementary files

Article information

Article type
Paper
Submitted
29 Jul 2013
Accepted
19 Sep 2013
First published
25 Sep 2013

RSC Adv., 2013,3, 24959-24963

Chemoenzymatic selective formation of C–N bonds in a benzimidazole heterocycle

H. Zheng, Q. Shi, K. Du, X. Cao and P. Zhang, RSC Adv., 2013, 3, 24959 DOI: 10.1039/C3RA43982H

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