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Issue 46, 2013
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Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

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Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

Graphical abstract: Rhenium(i) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

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Publication details

The article was received on 25 Jun 2013, accepted on 02 Oct 2013 and first published on 04 Oct 2013


Article type: Communication
DOI: 10.1039/C3RA43207F
Citation: RSC Adv., 2013,3, 23963-23966
  • Open access: Creative Commons BY license
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    Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

    C. Redshaw, S. Watkins, S. M. Humphrey, P. C. Bulman Page, S. Ashby, Y. Chao, C. J. Herbert and A. Mueller, RSC Adv., 2013, 3, 23963
    DOI: 10.1039/C3RA43207F

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