Issue 26, 2013
From the journal:

RSC Advances

Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water†

Vittorio Pace,*a   Laura Castoldi,a   Andrés R. Alcántarab  and  Wolfgang Holzera  

* Corresponding authors

a Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, Vienna, Austria
E-mail: vpace@farm.ucm.es
Fax: +43-1-4277-9556
Tel: +43-1-4277-55623

b Department of Organic and Pharmaceutical Chemistry, Complutense University of Madrid, Pza. Ramon y Cajal s/n, Madrid, Spain

Abstract

A straightforward chromatography-free preparation of Weinreb amides starting from acid halides has been achieved in the biphasic medium 2-MeTHF/water. Analytically pure compounds were isolated in excellent yields simply after removal of 2-MeTHF, which absolutely avoids the use of any contaminant organic solvent within the whole process due to its (practically) immiscibility with water.

Graphical abstract: Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water

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Article information

DOI
https://doi.org/10.1039/C3RA41262H
Article type
Communication
Submitted
03 Feb 2013
Accepted
12 Apr 2013
First published
15 Apr 2013

RSC Adv., 2013,3, 10158-10162

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Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water

V. Pace, L. Castoldi, A. R. Alcántara and W. Holzer, RSC Adv., 2013, 3, 10158 DOI: 10.1039/C3RA41262H

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