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Issue 6, 2013
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Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

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Abstract

Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of π-conjugation between the isoxazole and the AB modules.

Graphical abstract: Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

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Publication details

The article was received on 08 Nov 2012, accepted on 20 Nov 2012 and first published on 11 Dec 2012


Article type: Communication
DOI: 10.1039/C2RA22815G
Citation: RSC Adv., 2013,3, 1652-1655
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    Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

    C. Freeman, J. S. Vyle and F. Heaney, RSC Adv., 2013, 3, 1652
    DOI: 10.1039/C2RA22815G

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