Issue 3, 2013
From the journal:

RSC Advances

Suppressing regrowth of microfluidic generated drugnanocrystals using polyelectrolyte coatings†

Selvi Dev,a   Jeremiah Toster,a   S. Vadhan Prasanna,b   Melinda Fitzgerald,c   K. Swaminathan Iyera  and  Colin L. Raston*a  

* Corresponding authors

a Centre for Strategic Nano-Fabrication, School of Chemistry and Biochemistry, The University of Western Australia, Crawley WA 6009, Australia
E-mail: colin.raston@uwa.edu.au
Fax: +61 6488 8683

b Kilpauk Medical College, Chennai, 600010, India

c School of Animal Biology, The University of Western Australia, Crawley WA 6009, Australia

Abstract

Crystalline meloxicam nanoparticles <100 nm in diameter are accessible using a microfluidic platform without the use of organic solvents, with a subsequent layer-by-layer polyelectrolyte encapsulation being effective in suppressing growth of macrocrystals, and imparting high colloidal stability for sustained release over 6–8 h with a t1/2ca.180 min.

Graphical abstract: Suppressing regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings

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Article information

DOI
https://doi.org/10.1039/C2RA22790H
Article type
Communication
Submitted
06 Nov 2012
Accepted
07 Nov 2012
First published
07 Nov 2012

RSC Adv., 2013,3, 695-698

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Suppressing regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings

S. Dev, J. Toster, S. Vadhan Prasanna, M. Fitzgerald, K. Swaminathan Iyer and C. L. Raston, RSC Adv., 2013, 3, 695 DOI: 10.1039/C2RA22790H

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