Issue 4, 2013
From the journal:

RSC Advances

Pd-catalyzed C–H activation in water: synthesis of bis(indolyl)methanes from indoles and benzyl alcohols†

Hidemasa Hikawa*a  and  Yuusaku Yokoyama*a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
E-mail: hidemasa.hikawa@phar.toho-u.ac.jp, yokoyama@phar.toho-u.ac.jp

Abstract

A method for the synthesis of bis(indolyl)methanes via palladium-catalyzed domino reactions of indoles with benzyl alcohols was developed. This protocol involves C3-benzylation of indoles and benzylic C–H functionalization in water.

Graphical abstract: Pd-catalyzed C–H activation in water: synthesis of bis(indolyl)methanes from indoles and benzyl alcohols

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Article information

DOI
https://doi.org/10.1039/C2RA21887A
Article type
Communication
Submitted
22 Aug 2012
Accepted
17 Nov 2012
First published
21 Nov 2012

RSC Adv., 2013,3, 1061-1064

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Pd-catalyzed C–H activation in water: synthesis of bis(indolyl)methanes from indoles and benzyl alcohols

H. Hikawa and Y. Yokoyama, RSC Adv., 2013, 3, 1061 DOI: 10.1039/C2RA21887A

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