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Issue 12, 2012
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Copper-mediated synthesis of N-fused heterocycles via Csp–S coupling reaction and 5-endo-dig cyclization sequence

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Abstract

A novel method was developed for the preparation of N-fused heterocycles via a Csp–S coupling reaction and a sequence of 5-endo-dig cyclization. This method involves the reaction of –NHC(S)NH-containing compounds and alkynes in the presence of CuCl and N,N′-dicyclohexylimidazolium chloride.

Graphical abstract: Copper-mediated synthesis of N-fused heterocycles via Csp–S coupling reaction and 5-endo-dig cyclization sequence

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Publication details

The article was received on 13 Feb 2012, accepted on 19 Mar 2012 and first published on 20 Mar 2012


Article type: Communication
DOI: 10.1039/C2RA20254A
Citation: RSC Adv., 2012,2, 5054-5057
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    Copper-mediated synthesis of N-fused heterocycles via Csp–S coupling reaction and 5-endo-dig cyclization sequence

    D. Xiao, L. Han, Q. Sun, Q. Chen, N. Gong, Y. Lv, F. Suzenet, G. Guillaumet, T. Cheng and R. Li, RSC Adv., 2012, 2, 5054
    DOI: 10.1039/C2RA20254A

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