Issue 1, 2012
From the journal:

RSC Advances

Synthesis of glycoconjugated poly(amindoamine) dendrimers for targeting human liver cancer cells†

Rui Guo,ab   Ying Yao,c   Guangcun Cheng,c   Su He Wang,d   Yong Li,c   Mingwu Shen,a   Yuehua Zhang,d   James R. Baker, Jr.,,d   Jianhua Wang*c  and  Xiangyang Shi*ab  

* Corresponding authors

a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, People's Republic of China

b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People's Republic of China
E-mail: xshi@dhu.edu.cn
Fax: +86-21-67792306-804
Tel: +86-21-67792656

c Department of Biochemistry and Molecular & Cell Biology, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
E-mail: jianhuaw2007@gmail.com

d Michigan Nanotechnology Institute for Medicine and Biological Science, University of Michigan, Ann Arbor, MI, USA

Abstract

Amine-terminated generation 5 poly(amidoamine) dendrimers were utilized as a platform to conjugate fluorescein isothiocyanate and lactobionic acid. The conjugated lactobionic acid moieties enabled effective targeting to human liver cancer cells (HepG2) in vitro, which was demonstrated by both flow cytometry and confocal microscopy.

Graphical abstract: Synthesis of glycoconjugated poly(amindoamine) dendrimers for targeting human liver cancer cells

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Article information

DOI
https://doi.org/10.1039/C1RA00320H
Article type
Communication
Submitted
17 Jun 2011
Accepted
07 Oct 2011
First published
01 Nov 2011

RSC Adv., 2012,2, 99-102

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Synthesis of glycoconjugated poly(amindoamine) dendrimers for targeting human liver cancer cells

R. Guo, Y. Yao, G. Cheng, S. H. Wang, Y. Li, M. Shen, Y. Zhang, J. R. Baker, J. Wang and X. Shi, RSC Adv., 2012, 2, 99 DOI: 10.1039/C1RA00320H

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