Issue 6, 2018

Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

Abstract

An efficient one-pot approach to the synthesis of α,α-difluoroketone hydrazones has been developed via visible-light photoredox catalysis. The organic dye acts as an inexpensive and non-toxic photocatalyst, and could be recycled in 95% yield in a large-scale synthesis. This reaction occurs under mild conditions with high step-economy, a broad substrate scope, and excellent functional group compatibility. Moreover, the protocol is applicable to the late-stage functionalization of natural products.

Graphical abstract: Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

Supplementary files

Article information

Article type
Research Article
Submitted
15 Oct 2017
Accepted
16 Dec 2017
First published
18 Dec 2017

Org. Chem. Front., 2018,5, 1003-1007

Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

J. Li, L. Li, M. Zhou and H. Wang, Org. Chem. Front., 2018, 5, 1003 DOI: 10.1039/C7QO00939A

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