Issue 4, 2018

Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

Abstract

A nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed for the first time, demonstrating good efficiency, mild conditions, and good functional-group compatibility. The key to success is the combination of different kinds of readily available nitrogen and phosphine ligands with a nickel source, which can generate a variety of easily tunable catalysts in situ to promote the difluoromethylation of a broad scope of aryl boronic acids.

Graphical abstract: Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

Supplementary files

Article information

Article type
Research Article
Submitted
13 Oct 2017
Accepted
31 Oct 2017
First published
01 Nov 2017

Org. Chem. Front., 2018,5, 606-610

Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

J. Sheng, H. Ni, K. Bian, Y. Li, Y. Wang and X. Wang, Org. Chem. Front., 2018, 5, 606 DOI: 10.1039/C7QO00934H

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