Issue 12, 2017

Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates

Abstract

A novel protocol is herein described for the preparation of tri-/difluoromethylated N,N-dialkylhydrazones under transition-metal-free conditions and this reaction can be scaled up to the gram level easily. The reaction protocol is operationally simple and performed at ambient temperature, allowing obtaining the desired products in satisfactory yields. The easy-to-handle sodium tri- and difluoromethanesulfinates serve as effective fluoroalkyl radical precursors.

Graphical abstract: Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates

Supplementary files

Article information

Article type
Research Article
Submitted
25 Jul 2017
Accepted
23 Aug 2017
First published
24 Aug 2017

Org. Chem. Front., 2017,4, 2306-2310

Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates

X. Xu and F. Liu, Org. Chem. Front., 2017, 4, 2306 DOI: 10.1039/C7QO00635G

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