One step construction of a taxane-like skeleton by a diendiyne metathesis cyclization reaction

J. Otero-Fraga; J. R. Granja

doi:10.1039/C6QO00741D

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One step construction of a taxane-like skeleton by a diendiyne metathesis cyclization reaction†‡

J. Otero-Fraga

^a and J. R. Granja

*^a

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* Corresponding authors

^a Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: juanr.granja@usc.es

Abstract

One-step cyclization for the formation of the characteristic tricyclic system of taxanes is described. This process is based on a cascade metathesis cyclization reaction that allows the preparation of novel taxane derivatives in a fast and simple manner.

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Article information

DOI: https://doi.org/10.1039/C6QO00741D
Article type: Research Article
Submitted: 21 Nov 2016
Accepted: 23 Dec 2016
First published: 26 Dec 2016

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Org. Chem. Front., 2017,4, 460-466

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One step construction of a taxane-like skeleton by a diendiyne metathesis cyclization reaction

J. Otero-Fraga and J. R. Granja, Org. Chem. Front., 2017, 4, 460 DOI: 10.1039/C6QO00741D

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One step construction of a taxane-like skeleton by a diendiyne metathesis cyclization reaction†‡

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One step construction of a taxane-like skeleton by a diendiyne metathesis cyclization reaction

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