Issue 2, 2017

Aerobic copper catalyzed α-oxyacylation of ketones with carboxylic acids

Abstract

A copper catalyzed direct α-oxyacylation of ketones with carboxylic acids has been developed. Various acids including aromatic and aliphatic acids are well tolerated, and the scope of ketones is also investigated. This protocol provides a convenient and benign method for the synthesis of α-acyloxycarbonyl compounds by using oxygen as the oxidant. In addition, we have investigated the role of copper and trapped the key intermediate to confirm the mechanism.

Graphical abstract: Aerobic copper catalyzed α-oxyacylation of ketones with carboxylic acids

Supplementary files

Article information

Article type
Research Article
Submitted
23 Sep 2016
Accepted
14 Nov 2016
First published
16 Nov 2016

Org. Chem. Front., 2017,4, 163-169

Aerobic copper catalyzed α-oxyacylation of ketones with carboxylic acids

X. Huang, X. Liang, J. Yuan, Z. Ni, Y. Zhou and Y. Pan, Org. Chem. Front., 2017, 4, 163 DOI: 10.1039/C6QO00575F

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