Issue 11, 2016

LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

Abstract

An efficient and facile method for the synthesis of ortho-cyanated diarylmethane by reaction of fluoroarene with arylacetonitrile in the presence of LDA (lithium diisopropylamide) at room temperature was developed. The reaction of arylacetonitrile with electron-rich fluoroarene involves the formation of an aryne intermediate.

Graphical abstract: LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

Supplementary files

Article information

Article type
Research Article
Submitted
18 Jul 2016
Accepted
22 Aug 2016
First published
26 Aug 2016

Org. Chem. Front., 2016,3, 1425-1429

LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

F. Liang, X. Ji, J. Zhang and S. Cao, Org. Chem. Front., 2016, 3, 1425 DOI: 10.1039/C6QO00363J

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