AIEgen-functionalised mesoporous silica nanoparticles as a FRET donor for monitoring drug delivery

Abstract

Aggregation-induced emission luminogens (AIEgens), tetraphenylethene, were post grafted onto mesoporous silica nanoparticles to form AIEgen-functionalised mesoporous materials. The obtained blue-emitting materials can serve as a fluorescence resonance energy transfer (FRET) donor for monitoring the release process of doxorubicin hydrochloride (DOX) as an acceptor by the change of the fluorescent signal, showing potential application in imaging-guided therapy.