Chemoenzymatic synthesis of a peptide containing nylon monomer units for thermally processable peptide material application

Abstract

Peptides exhibit no melting behavior during heating due to their strong intermolecular hydrogen bonds, which limits the use of peptides as a bulk material. Here, we added a melting point to peptides by introducing nylon monomer units via papain-catalyzed chemoenzymatic synthesis. The peptides containing 14 mol% nylon units had a melting point of approximately 200 °C.