Issue 36, 2016
From the journal:

Polymer Chemistry

Injectable cationic hydrogels with high antibacterial activity and low toxicity†

Hong Du,‡a   Ying Wang,‡ab   Xuxia Yao,*c   Qiaojie Luo,bd   Weipu Zhu,*ae   Xiaodong Li*b  and  Zhiquan Shena  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: zhuwp@zju.edu.cn

b Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
E-mail: cisarli@zju.edu.cn

c School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: xuxia_yao@zju.edu.cn

d The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, P. R. China

e Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province, Hangzhou, China

Abstract

Antibacterial materials have always suffered from high toxicity. In this study, we fabricated injectable and biodegradable hydrogels utilizing poly(hexamethylene guanidine) hydrochloride and poly(ethylene glycol) as the backbone through a thiol–ene “click” reaction under physiological conditions, and they showed remarkably low toxicity and high and broad-spectrum antibacterial activity.

Graphical abstract: Injectable cationic hydrogels with high antibacterial activity and low toxicity

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Article information

DOI
https://doi.org/10.1039/C6PY01346E
Article type
Communication
Submitted
02 Aug 2016
Accepted
02 Aug 2016
First published
17 Aug 2016

Polym. Chem., 2016,7, 5620-5624

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Injectable cationic hydrogels with high antibacterial activity and low toxicity

H. Du, Y. Wang, X. Yao, Q. Luo, W. Zhu, X. Li and Z. Shen, Polym. Chem., 2016, 7, 5620 DOI: 10.1039/C6PY01346E

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