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Issue 5, 2016
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Modulating the cellular uptake of platinum drugs with glycopolymers

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Abstract

The therapeutic potency of platinum-based anticancer drugs can be substantially improved through the use of polymeric nanocarrier systems to target cancer cells efficiently. We synthesized a series of glyco-block copolymers with three different sugars able to self-assemble into nanoparticles when conjugated with 1,2-diamino-cyclopentane platinum(II) (DACP-Pt). The polymers are based on (2-(D-glucosyloxy)ethyl methacrylate (glucose; GlcMA), 2-(D-galactosyloxy)ethyl methacrylate (galactose; GalMA), 1-O-methacryloyl-β-D-fructopyranose (fructose; FrucMA1), and 3-O-methacryloyl-β-D-fructopyranose (fructose; FrucMA3)). They are all readily taken up intracellularly by the breast cancer cell lines MCF-7 and MDA-MB-231 and the ovarian cancer cell line A2780. All cell lines expressed a high preference for the fructose coated nanoparticles. The nanocarriers were themselves nontoxic, but exhibited high cytotoxicity and increased efficacy when conjugated with the DACP-Pt drug.

Graphical abstract: Modulating the cellular uptake of platinum drugs with glycopolymers

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Publication details

The article was received on 01 Oct 2015, accepted on 22 Nov 2015 and first published on 30 Nov 2015


Article type: Communication
DOI: 10.1039/C5PY01579K
Citation: Polym. Chem., 2016,7, 1031-1036
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    Modulating the cellular uptake of platinum drugs with glycopolymers

    A. Dag, M. Callari, H. Lu and M. H. Stenzel, Polym. Chem., 2016, 7, 1031
    DOI: 10.1039/C5PY01579K

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