Nanospheres, consisting of a Fe3O4 core, a silica inner shell and dendritic poly(ester amine) (PEA) outer shell, were synthesized via the sol–gel reaction, and successive Michael addition and alkyne–azide click chemistry. The resultant PEA dendrimer-grafted magnetic nanoparticles (Fe33O44-gg-PEA) were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and thermogravimetric (TGA) analysis. Transmission electron microscopy (TEM) images reveal that the Fe33O44-gg-PEA magnetic nanoparticles (MNPs) have a uniform size distribution of about 30 nm in diameter. The hydrodynamic size of Fe33O44-gg-PEAMNPs changes reversibly with pH of the aqueous medium in the pH range of 3 to 9. The clickable alkyne groups on the surface of Fe33O44-gg-PEAMNPs endow these nanoparticles with a functionalizable surface viaalkyne–azide click chemistry. Assays with 3T3 fibroblasts and RAW macrophage cells indicate that the Fe33O44-gg-PEAMNPs possess very low cytotoxicity. Hence, the PEA dendrimer-grafted magnetic nanospheres have potential applications as biomedical materials.
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