A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen production†
Abstract
We report a new class of photodynamic molecular beacon (PMB) with tumor specific mRNA-triggered control of singlet
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* Corresponding authors
a
Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Ontario, Canada
E-mail:
gang.zheng@uhnres.utoronto.ca
Fax: +1-416-581-7666
Tel: +1-416-581-7666
b Institute of Biomaterials and Biomedical Engineering, Toronto, Ontario, Canada
c Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
d Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
e Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
We report a new class of photodynamic molecular beacon (PMB) with tumor specific mRNA-triggered control of singlet
J. Chen, J. F. Lovell, P. Lo, K. Stefflova, M. Niedre, B. C. Wilson and G. Zheng, Photochem. Photobiol. Sci., 2008, 7, 775 DOI: 10.1039/B800653A
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