Issue 24, 2002

A facile route to pyrroles, isoindoles and hetero fused analogues

Abstract

Enamino acids derived from 1,2-dimethylaminomethylene- or 1,2-hydroxymethylene-carbonyl compounds and amino acids undergo a decarboxylative cyclisation to pyrroles, isoindoles and other fused pyrroles. A two atom ring expansion occurs preferentially with enamino acids from cyclohexane-1,3-diones and α-alkyl-α-amino acids leading to oxocino[2,3-c]pyrroles.

Graphical abstract: A facile route to pyrroles, isoindoles and hetero fused analogues

Article information

Article type
Paper
Submitted
20 Sep 2002
Accepted
14 Oct 2002
First published
25 Nov 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2799-2808

A facile route to pyrroles, isoindoles and hetero fused analogues

C. D. Gabbutt, J. D. Hepworth, B. M. Heron and S. L. Pugh, J. Chem. Soc., Perkin Trans. 1, 2002, 2799 DOI: 10.1039/B209255G

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