Issue 14, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4†

Stuart J. Conway,‡a   Jacqueline C. Miller,a   Andrew D. Bond,b   Barry P. Clarkc  and  David E. Jane*a  

* Corresponding authors

a Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK
E-mail: david.jane@bristol.ac.uk
Fax: +44 117 927 9839
Tel: +44 117 9287639

b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

c Eli Lilly & Co., Erl Wood Manor, Windlesham, Surrey, UK

Abstract

The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.

Graphical abstract: Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

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Article information

DOI
https://doi.org/10.1039/B204891D
Article type
Communication
Submitted
20 May 2002
Accepted
06 Jun 2002
First published
18 Jun 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1625-1627

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Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

S. J. Conway, J. C. Miller, A. D. Bond, B. P. Clark and D. E. Jane, J. Chem. Soc., Perkin Trans. 1, 2002, 1625 DOI: 10.1039/B204891D

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