Issue 18, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

An efficient synthesis of julibrosides related to neosaponin

Yuguo Du,a   Meimei Zhanga  and  Fanzuo Kong*a  

* Corresponding authors

a Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, China

Abstract

A practical method is developed for the synthesis of neosaponin cholest-5(6)-en-3β-yl β-D-glucopyranosyl-(1→3)-[α-L-arabinofuranosyl-(1→4)]-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside. This julibroside mimic shows cytotoxic activity towards P388 (mouse leukaemia) with GI50 = 22.5 μg mL−1.

Graphical abstract: An efficient synthesis of julibrosides related to neosaponin

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Article information

DOI
https://doi.org/10.1039/B009955O
Article type
Paper
Submitted
12 Dec 2000
Accepted
24 Jul 2001
First published
24 Aug 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2289-93

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An efficient synthesis of julibrosides related to neosaponin

Y. Du, M. Zhang and F. Kong, J. Chem. Soc., Perkin Trans. 1, 2001, 2289 DOI: 10.1039/B009955O

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