Issue 15, 2000

Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin

Abstract

A general modular approach to the members of the pederin family of antitumour agents is exemplified by syntheses of mycalamide B and theopederin D as well as a formal synthesis of pederin. All three compounds are prepared from 6-lithio-2,3-dimethyl-4-phenylselenomethyl-3,4-dihydro-2H-pyran and 2-(3-chloropropyl)-3,3-dimethyl-3,4-dihydro-2H-pyran-4-one.

Supplementary files

Article information

Article type
Paper
Submitted
16 Dec 1999
Accepted
24 Feb 2000
First published
23 May 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 2357-2384

Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin

P. Kocienski, R. Narquizian, P. Raubo, C. Smith, L. J. Farrugia, K. Muir and F. T. Boyle, J. Chem. Soc., Perkin Trans. 1, 2000, 2357 DOI: 10.1039/A909898D

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