Issue 22, 1998

One-pot synthesis of α-amino acids based on free radical-mediated carbon–carbon bond formation

Abstract

The one-pot reaction of 2-hydroxy-2-methoxyacetic acid methyl ester with benzyloxyamine and an alkyl radical provided a convenient method for preparing the protected α-amino acids via a carbon–carbon bond formation by intermolecular carbon radical addition to glyoxylic oxime ether.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1998, 3659-3660

One-pot synthesis of α-amino acids based on free radical-mediated carbon–carbon bond formation

H. Miyabe, N. Yoshioka, M. Ueda and T. Naito, J. Chem. Soc., Perkin Trans. 1, 1998, 3659 DOI: 10.1039/A807017B

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