SCHEDULED MAINTENANCE
A new chiral auxiliary (3S
)-N,N′-bis(p-methoxybenzyl)-3-isopropylpiperazine-2,5-dione 7 has been developed for the asymmetric synthesis of α-amino acids. The auxiliary 7 employs a novel chiral relay network based on non-stereogenic N-benzyl protecting groups which enhance the diastereoselectivity observed during alkylation of its C6 enolate 25.
S. D. Bull, S. G. Davies, S. W. Epstein, M. A. Leech and J. V. A. Ouzman, J. Chem. Soc., Perkin Trans. 1, 1998, 2321 DOI: 10.1039/A803124J
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