Issue 4, 1995

Structure and relative stereochemistry of a new polycyclic alkaloid, asparagamine A, showing anti-oxytocin activity, isolated from Asparagus racemosus

Abstract

The relative stereochemistry of a new cage-type alkaloid, asparagamine A 1, isolated from the roots of Asparagus racemosus Willd. (Liliaceae), has been elucidated by spectroscopic, chemical and single-crystal X-ray analyses. This novel polycyclic pyrrolizidine derivative is both the first alkaloid to be isolated from this genus and also the first pyrrolizidine derivative with carbon substituents at C-5 and C-8. The compound showed anti-oxytocin activity in vitro in a dose of 10–5–10–6 mg cm–3.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 391-393

Structure and relative stereochemistry of a new polycyclic alkaloid, asparagamine A, showing anti-oxytocin activity, isolated from Asparagus racemosus

T. Sekine, F. Ikegami, N. Fukasawa, Y. Kashiwagi, T. Aizawa, Y. Fujii, N. Ruangrungsi and I. Murakoshi, J. Chem. Soc., Perkin Trans. 1, 1995, 391 DOI: 10.1039/P19950000391

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