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Issue 20, 1994
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Indolizine studies. Part 3. Synthesis and dynamic NMR analysis of indolizine-2-carboxamides

Abstract

Reaction of indolizine-2-carboxylic acids with primary and secondary amines in the presence of 1,1′-carbonyldiimidazole provides convenient and efficient access to the corresponding secondary and tertiary amides and offers a significant improvement on previously reported methodology. The N–CO rotational barriers in the symmetrically substituted tertiary amides have also been explored using variable-temperature 1H and 13C NMR spectroscopy.

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Article type: Paper
DOI: 10.1039/P19940003023
Citation: J. Chem. Soc., Perkin Trans. 1, 1994,0, 3023-3027
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    Indolizine studies. Part 3. Synthesis and dynamic NMR analysis of indolizine-2-carboxamides

    M. L. Bode, P. T. Kaye and R. George, J. Chem. Soc., Perkin Trans. 1, 1994, 0, 3023
    DOI: 10.1039/P19940003023

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