Photocyclisation of enamides. Part 35. New total syntheses of the ergot alkaloids (±)-chanoclavine-1 and (±)-isochanoclavine-I using a fragmentation of 3-amino alcohols
Abstract
A new synthetic route involving the fragmentation reaction of 3-amino alcohols for the total synthesis of 6,7-secoergoline alkaloids was developed and then successfully applied to the total syntheses of (±)-chanoclavine-I and (±)-isochanoclavine-I.