Issue 6, 1991

Metabolites of the higher fungi. Part 26. Cubensic acid, 3,7,11,15-tetra hydroxy-18-(hydroxymethyl)-2,4,6,10,14,16,20-heptamethyldocosa-4E,8E,12E,16E-tetraenoic acid, a novel polysubstituted C22 fatty acid from the fungus Xylaria cubensis(Mont.) Fr. with substituents and substitution pattern similar to the macrolide antibiotics

Abstract

Cubensic acid, 3,7,11,15-tetrahydroxy-18-(hydroxymethyl)-2,4,6,10,14,16,20-heptamethyldocosa-4E,8E,12E,16E-tetraenoic acid, has been isolated from the mycelium and culture medium of Xylaria cubensis. Cytochalasin D is an additional metabolite isolated from the culture medium. The structure of cubensic acid has been determined by a combination of spectroscopic and chemical methods. A possible biosynthetic link between cubensic acid and certain macrolide antibiotics is suggested.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1991, 1411-1417

Metabolites of the higher fungi. Part 26. Cubensic acid, 3,7,11,15-tetra hydroxy-18-(hydroxymethyl)-2,4,6,10,14,16,20-heptamethyldocosa-4E,8E,12E,16E-tetraenoic acid, a novel polysubstituted C22 fatty acid from the fungus Xylaria cubensis(Mont.) Fr. with substituents and substitution pattern similar to the macrolide antibiotics

R. L. Edwards, D. J. Maitland and A. J. S. Whalley, J. Chem. Soc., Perkin Trans. 1, 1991, 1411 DOI: 10.1039/P19910001411

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements