A general procedure for the synthesis of dimethoxypyrimidines and uracils with highly functionalised C-5 substituents
Abstract
A versatile method for the synthesis of 5-[(3-alkyl or, 3-aryl-3-hydroxy)propynyl]-2,4-dimethoxypyrimidines (5)–(13), 5-(2-acyl-ethynyl)2,4-dimethoxypyrimidines (14)–(22), 5-(2-acyl-chlorovinyl)uracils (23)–(27) and 5-(2-acylethynyl)uracils (28)–(30) is described.