Preparations of perhydroimidazo[1,5-a]pyridine-3-thiones and thiazole-5-spirocyclopropan-4(5H)-ones from thioureas and α,γ-dibromobutyryl chloride under phase-transfer conditions
Abstract
The reaction of N-monosubstituted thioureas (1) with α,γ-dibromobutyryl chloride (2) was carried out in 5% NaOH–CH2Cl2 to afford 2-alkyl(aryl)-6-bromo-2,3,7,8-tetrahydro-3-thioxo-6,8a-ethano-imidazo[1,5-a]pyridine-1,5(6H,8aH)-diones (3) and 2-alkyl(aryl)-aminothiazole-5-spirocyclopropan-4(5H)-ones (5).