The synthesis of (±)-10a-homo-11a-carbathromboxane A1, a stable thromboxane A analogue
Abstract
The thromboxane A1(TXA1) analogue (1), which retains the characteristic bridge oxygen atom of the TXA molecule, has been synthesized from the bicyclic ketone (2). Stereochemical control of alkylation of the bicyclic ketone (2) was achieved by the use of enamines.