Optical activity as a consequence of an N–N-chiral axis: resolution of N-benzyl-N-(1,2-dihydro-2-oxo-1-quinolyl)glycine
Abstract
The title compound (6) has been synthesised and the pure, laevorotatory enantiomer separated via the quinine salt. Rates of racemisation give a barrier for rotation around the N–N bond of 26 ± 0.5 kcal mol–1.