Nucleophilic displacement reactions of 3,6-dichloropyridazine 1-oxide with sulphur nucleophiles
Abstract
The displacement reaction of 3,6-dichloropyridazine 1-oxide with sodium sulphide took place at the 6-position to give 3-chloropyridazine-6-thiol 1-oxide, in contrast to the results with oxygen and nitrogen nucleophiles. Other sulphur nucleophiles (thiourea and phenylmethanethiol) also reacted at the 6-position; this is inconsistent with a previously reported reaction with potassium methanethiolate.