Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines

P. R. Nitha; Manu M. Joseph; Greeshma Gopalan; Kaustabh Kumar Maiti; K. V. Radhakrishnan; Parthasarathi Das

doi:10.1039/C8OB01486H

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Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines†

P. R. Nitha,^ab Manu M. Joseph,^a Greeshma Gopalan,^ab Kaustabh Kumar Maiti,

*^ab K. V. Radhakrishnan

*^ab and Parthasarathi Das

*^c

Author affiliations

* Corresponding authors

^a National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram-19, India
E-mail: radhu2005@gmail.com

^b Academy of Scientific and Innovative Research (AcSIR), Thiruvananthapuram-19, India

^c Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad-826004, India
E-mail: partha@iitism.ac.in

Abstract

A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biological evaluation of cytotoxicity on selected examples provides scope for future investigations.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB01486H
Article type: Paper
Submitted: 23 Jun 2018
Accepted: 14 Aug 2018
First published: 14 Aug 2018

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Org. Biomol. Chem., 2018,16, 6430-6437

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Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines

P. R. Nitha, M. M. Joseph, G. Gopalan, K. K. Maiti, K. V. Radhakrishnan and P. Das, Org. Biomol. Chem., 2018, 16, 6430 DOI: 10.1039/C8OB01486H

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Organic & Biomolecular Chemistry

Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines†

Abstract

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Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines

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