Issue 21, 2018

Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

Abstract

A simple and efficient approach for the preparation of substituted indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction is reported. This transformation employed air-stable and inexpensive Ni(dppp)Cl2 as a precatalyst and Et3N as a mild base. Moreover, the reaction occurs efficiently under mild conditions, and a wide range of substituted indoles and isoquinolones bearing various functional groups are obtained in moderate to excellent yields.

Graphical abstract: Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

Supplementary files

Article information

Article type
Paper
Submitted
04 Apr 2018
Accepted
03 May 2018
First published
04 May 2018

Org. Biomol. Chem., 2018,16, 3983-3988

Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

W. Weng, J. Xie and B. Zhang, Org. Biomol. Chem., 2018, 16, 3983 DOI: 10.1039/C8OB00795K

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