Issue 17, 2018

A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

Abstract

Nitroreductase and acidity are common features of a tumor, which is associated with serious disease with a high mortality rate. However, solo detection of nitroreductase or acidic environments may cause false-positive results. Thus, it is very meaningful to develop dual functional probes for detecting nitroreductase and acidity, as these could be used for accurate tumor imaging. Here we report on the first dual functional ratiometric fluorescent probe, NAFP, for acidity and nitroreductase detection. This probe enables the measurement of the acidic microenvironment and the concentration of nitroreductase at the same time and the same site. The probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment. Furthermore, confocal fluorescence imaging of A549 cells indicates that NAFP can detect acidity and expressed nitroreductase in living cells.

Graphical abstract: A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

Supplementary files

Article information

Article type
Paper
Submitted
19 Mar 2018
Accepted
29 Mar 2018
First published
29 Mar 2018

Org. Biomol. Chem., 2018,16, 3266-3272

A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

Z. He, Y. Chou, H. Zhou, H. Zhang, T. Cheng and G. Liu, Org. Biomol. Chem., 2018, 16, 3266 DOI: 10.1039/C8OB00670A

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