Issue 16, 2018

Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

Abstract

Chemical reactions in a confined nanospace can be very different from those in solution. Imine formation between molecular amines and an aldehyde inside a molecularly imprinted receptor was promoted strongly by the binding. Although how well the amine fit in the binding pocket and its electronic nature both influenced the reaction, the freedom of movement for the amine was the most important factor determining the binding-normalized reactivity.

Graphical abstract: Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2018
Accepted
02 Apr 2018
First published
03 Apr 2018

Org. Biomol. Chem., 2018,16, 2855-2859

Author version available

Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

X. Xing and Y. Zhao, Org. Biomol. Chem., 2018, 16, 2855 DOI: 10.1039/C8OB00590G

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