Metal-free NaI/TBHP-mediated sulfonylation of thiols with sulfonyl hydrazides†
Abstract
A highly efficient sulfonylation of thiols has been achieved through the metal-free NaI/TBHP-mediated cross-coupling of sulfonyl hydrazides and thiols at room temperature. This method provides a convenient and practical route to thiosulfonates in 84–99% yields (39 examples) with wide functional group compatibility.
- This article is part of the themed collection: Synthetic methodology in OBC