Issue 45, 2017

Nanoprodrug of retinoic acid-modified paclitaxel

Abstract

All-trans-retinoic acid (RA) is a non-toxic physiological metabolite of vitamin A. A paclitaxel (PTX) prodrug (RA-PTX) with high PTX content of 75% was synthesized via an easy condensation reaction. RA-PTX nanoparticles (RA-PTX NPs) were prepared through a nanoprecipitation method which increased the water solubility of PTX. RA-PTX NPs were spherical in shape and exhibited favorable structural stability in both water and the physiological environment. RA-PTX NPs possessed effective cellular uptake as revealed by confocal laser scanning microscopy and exerted potent cytotoxicity. These results highlight the potential of nanomedicines from PTX prodrugs for increasing the drug loading and water solubility of PTX.

Graphical abstract: Nanoprodrug of retinoic acid-modified paclitaxel

Supplementary files

Article information

Article type
Paper
Submitted
16 Oct 2017
Accepted
27 Oct 2017
First published
27 Oct 2017

Org. Biomol. Chem., 2017,15, 9611-9615

Nanoprodrug of retinoic acid-modified paclitaxel

Z. Zhou, J. Yan, T. Sun, X. Wang and Z. Xie, Org. Biomol. Chem., 2017, 15, 9611 DOI: 10.1039/C7OB02553J

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