Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation: access to phosphorated 2H-indazoles

Weiwei Wei; Xuanyi Li; Meng Gu; Hequan Yao; Aijun Lin

doi:10.1039/C7OB02323E

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Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation: access to phosphorated 2H-indazoles†

Weiwei Wei,^a Xuanyi Li,^a Meng Gu,^a Hequan Yao

^a and Aijun Lin

*^a

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* Corresponding authors

^a State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University, Nanjing, P. R. China
E-mail: ajlin@cpu.edu.cn

Abstract

A novel Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation reaction between 2-alkynyl azobenzenes and P(O)H compounds has been developed. This reaction provides a convenient approach for the synthesis of various phosphorated 2H-indazoles in moderate to good yields, exhibiting good functional group tolerance and high atom economy.

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DOI: https://doi.org/10.1039/C7OB02323E
Article type: Paper
Submitted: 17 Sep 2017
Accepted: 18 Sep 2017
First published: 18 Sep 2017

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Org. Biomol. Chem., 2017,15, 8458-8462

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Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation: access to phosphorated 2H-indazoles

W. Wei, X. Li, M. Gu, H. Yao and A. Lin, Org. Biomol. Chem., 2017, 15, 8458 DOI: 10.1039/C7OB02323E

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Organic & Biomolecular Chemistry

Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation: access to phosphorated 2H-indazoles†

Abstract

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Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation: access to phosphorated 2H-indazoles

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