Issue 38, 2017

Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

Abstract

A general and mild method for the construction of a carbon–nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with α-aminocarbonyl compounds was achieved. Amines, either aliphatic primary amines, aromatic primary amines or secondary amines can be used as the starting materials. When R2 was different from R3, two isomers would be observed. Therefore, this reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.

Graphical abstract: Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug 2017
Accepted
01 Sep 2017
First published
01 Sep 2017

Org. Biomol. Chem., 2017,15, 8134-8139

Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

C. Chen, M. Zhu, L. Jiang, Z. Zeng, N. Yi and J. Xiang, Org. Biomol. Chem., 2017, 15, 8134 DOI: 10.1039/C7OB02012K

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