Issue 33, 2017

Nickel-catalyzed N-vinylation of heteroaromatic amines via C–H bond activation

Abstract

Here, we report a ligand- and reductant-free nickel-catalyzed N-vinylation of heteroaromatic amines using biorenewable p-cymene as a solvent. This unprecedented cross-coupling strategy has high functional group tolerance (halides, alkoxy, cyano, chiral motif, etc.) and proceeded via C–H bond activation.

Graphical abstract: Nickel-catalyzed N-vinylation of heteroaromatic amines via C–H bond activation

Supplementary files

Article information

Article type
Communication
Submitted
20 Jul 2017
Accepted
26 Jul 2017
First published
26 Jul 2017

Org. Biomol. Chem., 2017,15, 6896-6900

Nickel-catalyzed N-vinylation of heteroaromatic amines via C–H bond activation

V. G. Landge, J. Rana, M. Subaramanian and E. Balaraman, Org. Biomol. Chem., 2017, 15, 6896 DOI: 10.1039/C7OB01791J

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