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Issue 31, 2017
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Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

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Abstract

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92 : 8 er.

Graphical abstract: Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

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Publication details

The article was received on 23 Jun 2017, accepted on 17 Jul 2017 and first published on 18 Jul 2017


Article type: Communication
DOI: 10.1039/C7OB01527E
Citation: Org. Biomol. Chem., 2017,15, 6474-6477
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    Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

    J. Li, Y. Fu, C. Qin, Y. Yu, H. Li and W. Wang, Org. Biomol. Chem., 2017, 15, 6474
    DOI: 10.1039/C7OB01527E

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